解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:Background:Cavitary lesions (CLs) primarily identified by chest x-ray (CXR) have been associated with worse clinical outcomes among patients with pulmonary tuberculosis (PTB). Chest computed tomography (CT), which has better resolution and increased sensitivity to detect lung abnormalities, has been understudied in PTB...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz232
更新日期:2019-06-24 00:00:00
abstract:Background:Little information is available on the relative tolerability of ceftaroline versus other cephalosporins in clinical practice. We sought to compare adverse drug reactions (ADRs) associated with ceftaroline with those associated with ceftriaxone in hospitalized patients. Materials and Methods:This was a retro...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz279
更新日期:2019-06-13 00:00:00
abstract:Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz283
更新日期:2019-06-11 00:00:00
abstract:Background:Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV (PWH). We examined the association of the kyn/trp ratio with liver fibrosis in women with/without HIV infection. Methods:The plasma kyn/trp ratio was measured in 137...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz281
更新日期:2019-06-11 00:00:00
abstract::Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distin...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz263
更新日期:2019-06-01 00:00:00
abstract:Background:Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods:In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared antibiotic treat...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz243
更新日期:2019-05-21 00:00:00
abstract::Although it is intuitive that antibiotics administered before obtaining a blood culture would reduce the likelihood of obtaining a positive culture, it is not clear exactly how rapidly and to what extent blood becomes sterile after administration of intravenous (IV) antibiotics. Using a large data set of patients admi...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz179
更新日期:2019-05-20 00:00:00
abstract:Background:Although existing literature supports durations of 5-7 days for skin and soft tissue infections (SSTIs), longer durations are commonly used. Obesity and heart failure (HF) have been associated with increased risk for treatment failure of SSTIs; however, whether prolonged antibiotic durations reduce the risk ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz217
更新日期:2019-05-07 00:00:00
abstract:Background:Hepatitis C virus (HCV), a major cause of morbidity and mortality, is common and rising among young persons who inject drugs (PWID). Reducing the level of viremia may be an intervention, yet the impact of viremia on HCV transmission is unknown. Methods:We conducted a prospective study of injecting partnersh...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz125
更新日期:2019-04-25 00:00:00
abstract:Background:Patients with suspected tuberculosis are often overtreated with antituberculosis drugs. We evaluated the diagnostic value of the focused assessment with sonography for HIV-associated tuberculosis (FASH) in rural Tanzania. Methods:In a prospective cohort study, the frequency of FASH signs was compared betwee...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz154
更新日期:2019-04-25 00:00:00
abstract:Background:Recent observations provide evidence for group-specific immunity toward influenza A infections and raise the question of how often we can get the flu. Methods:We retrospectively analyzed 2308 cases of children and adolescents with clinically manifested influenza and a positive PCR-test during the last 4 epi...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz195
更新日期:2019-04-23 00:00:00
abstract:Background:During antiretroviral therapy (ART), HIV-1-infected patients may present with ultralow (UL) HIV-RNA viral loads (VLs) below quantification levels of current assays. Reasons for UL-VL detection and its relation to virological rebound (VR) are unclear. Methods:HIV-1-infected, ART-naïve patients followed at 2 ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz177
更新日期:2019-04-10 00:00:00
abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章,已发布勘误
doi:10.1093/ofid/ofz142
更新日期:2019-04-03 00:00:00
abstract:Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz158
更新日期:2019-03-29 00:00:00
abstract::Surveillance represents an important informational tool for planning actions to monitor emerging antimicrobial resistance. Antimicrobial resistance surveillance (ARS) programs may have many different designs and can be grouped in 2 major categories based on their main objectives: (1) public health ARS programs and (2)...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy345
更新日期:2019-03-15 00:00:00
abstract:Background:The Short Physical Performance Battery (SPPB) is a well regarded physical functioning assessment including balance, gait speed, and chair-stand tests. Its use has not been widely assessed in human immunodeficiency virus (HIV) care. We evaluated the feasibility of integrating the SPPB into care of aging peopl...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz038
更新日期:2019-03-11 00:00:00
abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz090
更新日期:2019-02-26 00:00:00
abstract:Background:Maintaining retention in preexposure prophylaxis (PrEP) care among diverse patient populations will be needed to support PrEP's efficacy. We characterized patterns of PrEP care retention in a US municipal primary care health network and examined whether missed visits, a metric of care retention that is easy ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz101
更新日期:2019-02-26 00:00:00
abstract:Background:Hepatitis C remains a major cause of liver disease globally and is responsible for approximately 500 000 deaths annually. Newer direct-acting antivirals achieve cure rates at or above 90% with excellent tolerability for most patients. The literature focusing on identification of predictors of efficacy and sa...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz087
更新日期:2019-02-19 00:00:00
abstract:Background:The objective of this study was to investigate the difference in disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome end points. Methods:A prospective, observational study was conducted over the 2016-2018 influenza seasons in a centr...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz053
更新日期:2019-02-15 00:00:00
abstract::Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understand the immune respon...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz046
更新日期:2019-02-06 00:00:00
abstract:Background:Concomitant dosing of ledipasvir (LDV) and tenofovir disoproxil fumarate (TDF) results in an increased tenofovir (TFV) area under the curve (AUC). The aim of this study was to examine whether there was a correlation between the renal biomarkers retinol binding protein-4 (RBP-4) and β2 microglobulin (β2M) and...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy273
更新日期:2019-01-24 00:00:00
abstract:Background:Retention in care (RIC) and viral suppression (VS) are associated with reduced HIV transmission and mortality. Studies addressing postpartum engagement in HIV care have been limited by small sample size, short follow-up, and a lack of data from the Southeast United States. Methods:HIV-positive adult women w...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz023
更新日期:2019-01-19 00:00:00
abstract::Burkholderia pseudomallei and Burkholderia cepacia complex are poorly studied in Mexico. The genotypic analysis of 38 strains isolated from children with pneumonia were identified and showed that both Burkholderia groups were present in patients. From our results, it is plausible to suggest that new species are among ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz008
更新日期:2019-01-18 00:00:00
abstract:Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofz018
更新日期:2019-01-18 00:00:00
abstract:Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study w...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy340
更新日期:2018-12-15 00:00:00
abstract:Background:There is growing interest in the use of rapid blood culture identification (BCID) in antimicrobial stewardship programs (ASPs). Although many studies have looked at its clinical and economic utility, its comparative utility in gram-positive and gram-negative blood stream infections (BSIs) has not been as wel...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy308
更新日期:2018-12-11 00:00:00
abstract:Background:Few studies have investigated predictors of serological response to syphilis treatment in people living with HIV (PLWH). Methods:This was a retrospective, longitudinal study on PLWH who were diagnosed with and treated for syphilis who had an assessable serological response between January 2004 and June 2016...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy324
更新日期:2018-11-30 00:00:00
abstract::We implemented a real-time report to distribute respiratory pathogen data for our 8-hospital system to anyone with an Internet connection and a web browser. Real-time access to accurate regional laboratory observation data during an epidemic influenza season can guide diagnostic and therapeutic strategies. ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy322
更新日期:2018-11-30 00:00:00
abstract:Background:This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size. Methods:We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 ant...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy201
更新日期:2018-11-16 00:00:00
abstract::International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy297
更新日期:2018-11-16 00:00:00
abstract:Background:There are few longitudinal data on the risk factors and mediators of racial disparities in sepsis among community- dwelling US adults. Methods:This is a longitudinal study of adult participants in the 1999-2005 National Health Interview Survey with data linked to the 1999-2011 National Death Index. We utili...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy305
更新日期:2018-11-15 00:00:00
abstract:Background:Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition. Me...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy288
更新日期:2018-11-05 00:00:00
abstract:Background:Patients heterozygous for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more susceptible to respiratory infections than the general population. Methods :We conducted a retrospective case-control study using health insurance claims. We identified patients as either h...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy219
更新日期:2018-11-01 00:00:00
abstract::Interpretive criteria for in vitro susceptibility testing criteria, "susceptibility breakpoints," underpin the evaluation and selection of antimicrobial regimens. However, despite their strengths, susceptibility breakpoints are a relatively blunt instrument employed to address an extremely complex question-what is the...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy282
更新日期:2018-10-31 00:00:00
abstract:Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy278
更新日期:2018-10-24 00:00:00
abstract:Background:Cytomegalovirus (CMV) mononucleosis is a manifestation of primary CMV infection. This study aims to establish the link between long-term population CMV seroepidemiological trends and incidence of CMV mononucleosis requiring hospitalization. Furthermore, by analyzing serial laboratory data of patients hospita...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy262
更新日期:2018-10-20 00:00:00
abstract:Background:The United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015-2016 mumps outbreak at the University of Iowa, we estimated the c...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy199
更新日期:2018-10-04 00:00:00
abstract::Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patie...
journal_title:Open forum infectious diseases
pub_type: 杂志文章,评审
doi:10.1093/ofid/ofy213
更新日期:2018-09-26 00:00:00
abstract:Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...
journal_title:Open forum infectious diseases
pub_type: 杂志文章
doi:10.1093/ofid/ofy234
更新日期:2018-09-15 00:00:00